Relationship Between CYP 2D6 Metabolic Status and Sexual Dysfunction in Paroxetine Treatment

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	ŽOURKOVÁ Alexandra HADAŠOVÁ Eva
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Journal of Sex and Marital Therapy
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	sexual dysfunction; CYP2D6; paroxetine; poor metabolizer
Description	This article describes the incidence of sexual dysfunction in 30 patients subjected to long-term treatment by paroxetine in dependence on the P 450 CYP 2D6 isoenzyme metabolic status. Measured on the Arizona Sexual Experience Scale (ASEX; McGahuey, Delgado, & Gelenberg, 1999), the incidence of sexual dysfunction inpatients converted to CYP 2D6 poor metabolizers was markedly higher compared with patients who had no history of such conversion, a difference that reached the level of statistical significance. Our article discusses the incidence of sexual dysfunction in connection with reduced CYP 2D6 capacity.
Related projects:	Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates Plasticity of Regulatory Mechanisms of the Central Nervous Systems