The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence

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Authors	ŠERÝ Omar VOJTOVÁ Veronika ZVOLSKÝ Petr
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Physiological Research
MU Faculty or unit	Faculty of Science
Citation
Field	Physiology
Keywords	TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence
Description	We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found.
Related projects:	Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism. Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children Molecular pathophysiology of multigene diseases