Apoptóza satelitních buněk spinálních ganglií po centrální axotomii

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Title in English	Satellite cell apoptosis in the dorsal root ganglia after central axotomy
Authors	KLUSÁKOVÁ Ilona DUBOVÝ Petr SVÍŽENSKÁ Ivana
Year of publication	2001
Type	Article in Proceedings
Conference	Nové poznatky v morfológii
MU Faculty or unit	Faculty of Medicine
Citation
Field	Morphological specializations and cytology
Description	The intact DRG and DRG after central axotomy displayed approximately the same number of satellite cells. Two weeks after central axotomy we found a reasonable elevation of mean percentage of neurons surrounded by TUNEL+ satellite cells. We found noticeable increase of the value after 4 weeks post transection. The similar increase in mean percentage of TUNEL+ satellite cells was found. A robust increase of TUNEL+ satellite cells was demonstrated in the group of C neurons. Despite evidence of increasing level of apoptosis, the number of satellite cells around individual types of neurons in axotomized DRG maintained at the same level. The results suggest a course of apoptosis simultaneously with proliferation to preserve a balance of the cell number.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems