Olfactory bulbectomy increases methamphetamine i.v. self-administration in rats

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Authors	NOVÁKOVÁ Jana PISTOVČÁKOVÁ Jana VINKLEROVÁ Jana ŠULCOVÁ Alexandra
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Behavioural Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Description	The rats with olfactory bulbectomy (OB rats) show behavioural and endocrine changes resembling those found in human depression. From clinics depressive patients are reported to be more vulnerable towards a consumption of drugs of abuse. Our results confirm the suggestion that OB rats also incline to a greater intake of methamphetamine using the animal model of "i.v. drug self-administration".
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems