The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population

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Authors	BENEŠ Petr MUŽÍK Jan BENEDÍK Jaroslav ELBL Lubomír VAŠKŮ Anna ŠIŠKOVÁ Lenka ZNOJIL Vladimír VÁCHA Jiří
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Journal of Molecular Medicine
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins
Description	Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients.
Related projects:	Molecular pathophysiology of selected multigenic related to civilization diseases Molecular pathophysiology of multigene diseases