Aktivita cytochromu P450-2D6 a N-acetyltransferázy v izolovaných perfundovaných játrech potkana po podání agonistů 5-HT receptorů

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Title in English	Activity of cytochrome P450-2D6 a N-acetyltransferase in the isolated perfused rat liver after administration of agonists of 5-HT receptors
Authors	JUSTINOVÁ Zuzana PISTOVČÁKOVÁ Jana TOMANDLOVÁ Marie HADAŠOVÁ Eva
Year of publication	2000
Type	Article in Periodical
Magazine / Source	Československá fyziologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Cytochrome P450; N-acetyltransferase; 5-HT1 agonists; rat; liver
Description	Influence of selected agonists of 5-HT1 receptors on the activity of CYP 2D and NAT2 was followed in the isolated liver of rat donors. The results showed that RU-24969 and CGS 12066B inhibited the CYP2D activity, but they did not affect NAT2 activity. Sumatriptan slightly inhibited NAT2 activity and did not influence the oxidative metabolism in the liver.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems