The effects of Fos proteins on myeloid differentiation

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Authors	ZAHRADNÍČKOVÁ Eva ŠEVČÍKOVÁ Sabina SOUČEK Karel ŠMARDA Jan
Year of publication	2001
Type	Article in Proceedings
Conference	V. Pracovní setkání biochemiků a molekulráních biologů
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Fos
Description	The line of v-myb-transformed chicken monoblasts BM2 is a suitable model for study of myeloid differentiation. These cells proliferate in monoblastic stage and their terminal differentiation steps are blocked. We found that overexpression of v-fos and c-fos causes growth arrest of BM2 cells. To clarify this observation we performed cell cycle analysis. We found that c-Fos partially induces apoptosis while v-Fos rather affects cell cycle of BM2 cells.
Related projects:	Genomes and their functions