Nanomaterial Patches as a New Possible Alternative for The Treatment of Gastrointestinal Lesions in an Experimental In Vivo Model
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| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
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| Description | This study evaluated the potential of PHB nanopatches as an alternative to traditional sutures for repairing intestinal wall defects in a laboratory rat model. A total of 48 sexually mature rats were divided into three groups, each receiving different treatments: plasma-treated PHB patches, PLA patches, or simple surgical sutures. All procedures were performed under general anesthesia, fol- lowed by antibiotic therapy for seven days. Animals were monitored for one or two weeks post-sur- gery, with no unexpected deaths or signs of severe complications such as abscesses or peritonitis observed. Macroscopic healing was achieved in all cases, and microbial contamination was absent in abdom- inal swab cultures. Histological analysis revealed varying degrees of mucosal ulceration among the groups, with fewer instances in the PHB-treated group compared to PLA patches and sutures. Patch dislocation occurred in isolated cases but did not result in intra-abdominal complications. These preliminary findings highlight the feasibility of using PHB nanopatches for intestinal wall re- pair, demonstrating uncomplicated healing and minimal adverse effects. However, further research is required to optimize the material’s adhesiveness and reduce unintended adhesion to surrounding tissues. While PLA patches showed persistent ulceration, PHB patches exhibited promising results. Future studies should focus on long-term healing outcomes and material biodegradation over ex- tended follow-up periods to refine this innovative approach. |
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