EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF BROUSSOFLAVONOL B IN A MODEL OF INDUCED PLANTAR EDEMA IN LABORATORY MICE

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Authors

SUCHÝ Pavel MALANÍK Milan CHALUPOVÁ Marta ARAČI Noemi PARÁK Tomáš KUZMÍNOVÁ Gabriela ŠMEJKAL Karel

Year of publication 2025
Type Conference abstract
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Prenylated phenols are natural substances that are used in traditional medicine for their wide range of biological effects. Broussoflavonol B was isolated from Broussonetia papyrifera with various biological activities, such as antioxidant, and anti-inflammatory activity. The anti-inflammatory activity of broussoflavonol B has been described in vitro, and inhibition of NF-?B and IL-1ß activity has been demonstrated. The next step in the investigation of the biological activity of these natural compounds is to verify their anti-inflammatory potential in vivo. The experiment follows the previous in vitro research phases, which confirmed the anti-inflammatory activity of the selected natural substances.
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