Cathelicidins as antibacterial and antibiofilm agents against multidrug-resistant Pseudomonas aeruginosa

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Authors	VOLNÝ Frederik ŠEFRANKO Marko VACEK Lukáš PAVELKA Antonín JANDA Lubomír RŮŽIČKA Filip
Year of publication	2025
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Pseudomonas aeruginosa is a multidrug-resistant pathogen requiring alternative therapies. This study evaluated antibacterial and antibiofilm effects of five cathelicidins, naturally occurring antimicrobial peptides, and their combinations against 19 clinical strains. All tested strains were susceptible to at least one cathelicidin. The LL-37/SMAP-29 combination exhibited the strongest synergistic effect.
Related projects:	Léčba infekcí způsobených multirezistentními kmeny bakterií pomocí nových antibakteriálních přípravků založených na katelicidinových antimikrobiálních peptidech