Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia
Authors | |
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Year of publication | 2025 |
Type | Article in Periodical |
Magazine / Source | Haematologica |
MU Faculty or unit | |
Citation | |
web | https://haematologica.org/article/view/11946 |
Doi | https://doi.org/10.3324/haematol.2024.287062 |
Keywords | Blinatumomab; acute lymphoblastic leukemia; Ph- B-cell precursor |
Attached files | |
Description | Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable residual disease (MRD) negativity. In the MRD setting, blinatumomab induced MRD negativity (MRDneg) in 78% of patients, with 85% achieving MRD <10-. Patients treated in their first complete remission (CR) showed better outcomes than those treated in later remissions. These findings support integrating blinatumomab into first-line polychemotherapy, as early MRD clearance significantly improves survival and reduces risk of relapse. |
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