In-phase and anti-phase responses of coupled interneurons to external current stimuli
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| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Over the last decade, high-frequency oscillations (HFOs), very high-frequency oscillations (VHFOs), and ultra-fast oscillations (UFOs) have been proposed as potential biomarkers for epileptogenic zones in patients with drug-resistant epilepsy. However, the mechanisms generating such high frequencies, significantly exceeding neuronal firing limits, remain unclear. Using bifurcation theory, we propose a mathematical framework for modeling apparent VHFOs in depth EEG signals through anti-phase synchronization of neuronal populations. Focusing on a pair of gap-junctionally coupled interneurons, we analyze multistable regions and dynamical regimes related to external current stimulation, analogous to the frequency-input curve of a single interneuron. Moreover, we detail the stimulus's ability to activate, deactivate, or switch oscillation modes between in-phase and anti-phase. Finally, we apply this framework to analyze the collective response of a large heterogeneous two-layer network. |
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