Rozdíly mezi pohlavími - od farmakologie až po metodologii klinického výzkumu
| Title in English | Sex-related differences - from pharmacology to clinical research methodology |
|---|---|
| Authors | |
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | Klinická Farmakologie a Farmacie |
| MU Faculty or unit | |
| Citation | |
| web | https://klinickafarmakologie.cz/pdfs/far/2025/01/06.pdf |
| Doi | http://dx.doi.org/10.36290/far.2025.019 |
| Keywords | sex differences; clinical research; trial methodology; under-served population |
| Description | Expert community and even patients are increasingly concerned about whether the results of clinical trials can be applied to patient subgroups that were not originally included in the research. Regarding this, female population is the most frequently discussed. Biological sex significantly influences the pharmacokinetics and pharmacodynamics of drugs, leading to differences in both therapeutic and adverse effects. Despite this, women have been historically under-represented in clinical studies, for example in cardiovascular research. Although female participation has improved in recent years, disparities persist. This article explores the historical development of female representation in clinical research and analyzes the current state of the field. It also discusses the optimal inclusion of women in studies and proposes strategies to achieve this goal, ensuring the collection of reliable data applicable to both sexes. These steps will contribute to the optimization of treatment protocols that account for sex-based differences. |
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