Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | Heart Rhythm |
| MU Faculty or unit | |
| Citation | |
| web | https://www.heartrhythmjournal.com/article/S1547-5271(25)00201-2/fulltext |
| Doi | http://dx.doi.org/10.1016/j.hrthm.2025.02.031 |
| Keywords | Bradycardia; Conduction system pacing; Echocardiography; RV pacing; UHF-ECG; Ventricular dyssynchrony |
| Attached files | |
| Description | Background: Ultra-high-frequency electrocardiography (UHF-ECG) is a noninvasive tool visualizing the ventricular activation sequence. It was never compared with other methods of dyssynchrony assessment in patients with bradycardia. Objective: We aimed to compare UHF-ECG interventricular electrical dyssynchrony (e-DYS) with interventricular mechanical delay (IVMD) measured by echocardiography in patients receiving right ventricular pacing (RVP) or conduction system pacing (CSP). Methods: Fifty-three patients with advanced atrioventricular conduction disease and preserved ventricular systolic function were prospectively assigned to RVP (n=32 [60 %]) or CSP (n=21 [40 %]). IVMD was measured as the time difference between left ventricular and right ventricular preejection periods. Interventricular e-DYS was calculated by software as the time difference between activation in V1 and V7 chest electrodes using UHF-ECG. Results: The median age of patients was 75 (interquartile range 72-80) years, and both groups had similar clinical characteristics. Baseline IVMD and interventricular e-DYS were similar in the entire population (-2 [-8 to 5] ms vs-1 [-6 to 5] ms, respectively; P=.52). Both methods showed the same dyssynchrony trends after pacemaker implantation; that is, while both IVMD and interventricular e-DYS increased in the RVP group (IVMD 28 [23-33] ms vs interventricular e-DYS 26 [19-33] ms; P=.99), they remained low in the CSP group (IVMD -7 [-16 to 2] ms vs interventricular e-DYS -5 [-12 to 2] ms; P=.91). There was a moderate overall correlation between IVMD and interventricular e-DYS for all studied ventricular rhythms (R=0.74). Conclusion: UHF-ECG noninvasively expresses interventricular dyssynchrony from V7-V1 chest leads with similar results to echocardiography. RVP increases interventricular dyssynchrony, while CSP preserves synchronous ventricular activation. |
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