The role of long non-coding RNAs in BCR-mediated CLL activation.

Investor logo
Investor logo

Warning

This publication doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

FARIA ZENI Pedro MEDKOVÁ Michaela TRACHTOVÁ K. JANSKÁ L. ŠEDA Václav HOFERKOVÁ Eva VARADARAJAN Nandan Mysore SHARMA Sonali OBRDLÍK Aleš VAŇÁČOVÁ Štěpánka MAIQUES-DIAZ A. MARTÍN-SUBERO JI. MRÁZ Marek

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Attached files
Description B cell Receptor (BCR) plays a pivotal role in providing maturation and survival signals for B cells. However, dysregulation of the BCR pathway is a fundamental characteristic observed in numerous B cell malignancies, including chronic lymphocytic leukemia (CLL), revealing its importance in disease progression. Despite the absence of recurrent mutations found in the BCR-related genes of untreated cases, BCR inhibitors have shown a universal clinical response in CLL patients. We and others have shown that short non-coding RNAs, namely microRNAs, can (dys)regulate the BCR signaling propensity, but it is still unclear if long non-coding RNAs (lncRNAs) play a role in BCRactivation. Hence, we hypothesized that lncRNAs could be involved in BCR-mediated CLL activation. To address our hypothesis, we performed differential lncRNA expression analysis in CLL cells from patients treated with BCR inhibitors and cross-validated in CLL intraclonal subpopulations with high BCR activity (CXCR4dim CD5bright) vs. low BCR activity (CXCR4bright CD5dim). We found 12 lncRNAs related to the BCR pathway inhibition/activity. Out of these lncRNAs, we selected a lncRNA that belongs to a class of lncRNA called long intergenic non-coding RNA (lincRNAs) which often play a role in trans-activating signaling pathways.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info