Depressive-like phenotype enhances relapse of nicotine seeking after forced abstinence in rats

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Authors	AMCHOVÁ Petra RUDÁ Jana
Year of publication	2023
Type	Article in Periodical
Magazine / Source	The World Journal of Biological Psychiatry
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2070665
Doi	https://doi.org/10.1080/15622975.2022.2070665
Keywords	abuse; depression; nicotine; olfactory bulbectomy; rats; self-administration
Description	Comorbidity of depression and drug addiction is common, but effective treatment is missing. A rat model combining the olfactory bulbectomy (OBX) model and IV drug self-administration has provided evidence of differential reactivity of the OBX rats towards drugs of abuse. This study evaluates nicotine taking and seeking behavior in this model.
Related projects:	Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii