On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy

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Authors	SORZANO Carlos JIMÉNEZ-MORENO Amaya MALUENDA David MARTÍNEZ Marta RAMÍREZ-APORTELA Erney KRIEGER James MELERO Roberto CUERVO Ana CONESA Javier FILIPOVIČ Jiří CONESA Pablo CANO Laura del FONSECA Yunior LA MORENA Jorge Jiménez-de LOSANA Patricia SÁNCHEZ-GARCÍA Ruben STŘELÁK David FERNÁNDEZ-GIMÉNEZ Estrella DE ISIDRO-GÓMEZ Federico HERREROS David VILAS Jose Luis MARABINI Roberto CARAZO Jose Maria
Year of publication	2022
Type	Article in Periodical
Magazine / Source	Acta Crystallographica Section D: Structural Biology
MU Faculty or unit	Faculty of Informatics
Citation
Web	https://doi.org/10.1107/S2059798322001978
Doi	http://dx.doi.org/10.1107/S2059798322001978
Keywords	single-particle analysis; cryo-electron microscopy; parameter estimation; image processing; bias; variance; overfitting; gold standard