Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide

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Authors

ONUŠČÁKOVÁ Magdaléna PÍŽOVÁ Hana KAUEROVÁ Tereza KOLLÁR Peter BOBÁĽ Pavel

Year of publication 2021
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Histone acetylation is a process controlled by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an essential role in the regulation of gene expression. HDACs are a family of enzymes that modulate the acetylation status of histones and non-histone proteins. Inhibitors of HDAC (HDACi), which form a complex with Zn2+ ion in the enzyme active site, are novel antiproliferative agents that induce tumor cell death, differentiation, and/or cell cycle arrest.
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