The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

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Authors

GRILLOVÁ Linda MUSILOVA Jana JANEČKOVÁ Klára POSPÍŠILOVÁ Petra KUKLOVA Ivana WOZNICOVÁ Vladana ZAKOUCKA Hana ŠMAJS David

Year of publication 2021
Type Article in Periodical
Magazine / Source INFECTION AND IMMUNITY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://journals.asm.org/doi/epub/10.1128/IAI.00503-20
Doi http://dx.doi.org/10.1128/IAI.00503-20
Keywords Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study
Description Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
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