Dasatinib treatment long-term results among imatinib-resistant/intolerant patients with chronic phase chronic myeloid leukemia are favorable in daily clinical practice

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Authors

ŽÁČKOVÁ Daniela KLAMOVA Hana BELOHLAVKOVA Petra STEJSKAL Lukas NEČASOVÁ Tereza SEMERÁD Lukáš WEINBERGEROVÁ Barbora SRBOVA Dana VOGLOVA Jaroslava ČIČÁTKOVÁ Petra ŠUSTKOVÁ Zuzana HORŇÁK Tomáš BARANOVÁ Jana PROCHÁZKOVÁ Jiřina MAYER Jiří

Year of publication 2021
Type Article in Periodical
Magazine / Source LEUKEMIA & LYMPHOMA
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1827242
Doi http://dx.doi.org/10.1080/10428194.2020.1827242
Keywords Chronic myeloid leukemia; chronic phase; imatinib; dasatinib; second line; daily clinical practice
Description To evaluate long-term real-life results of dasatinib therapy among chronic phase chronic myeloid leukemia patients resistant or intolerant to imatinib, we retrospectively analyzed data of 118 patients treated in centers participating in the database INFINITY. With median follow-up of 37 months, estimated 5-year cumulative incidences of complete cytogenetic and major molecular responses were 78% and 68%, respectively. The estimated 5-year probability of overall survival (OS) and event-free survival (EFS) were 86% and 83%, respectively. Both OS and EFS were significantly improved among patients withBCR-ABL1transcript level <= 10% at 3 months. Dasatinib toxicity was tolerable however persistent in almost half our patients, even after years of therapy. Pleural effusion occurred in 29% of patients and was responsible for 30% of dasatinib discontinuations. Our results confirmed very good efficacy and acceptable toxicity of dasatinib in second line setting and support the evidence and importance of high-quality real-life CML patient management.
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