Minor-clone TP53 mutations in CLL patients entering first-line treatment: clonal evolution and clinical impact.

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Authors	MALČÍKOVÁ Jitka PAVLOVÁ Šárka VONKOVÁ Barbara KOTAŠKOVÁ Jana RADOVÁ Lenka PLEVOVÁ Karla ŽENATOVÁ Marcela HYNŠT Jakub DVOŘÁČKOVÁ Barbara PANOVSKÁ Anna BRYCHTOVÁ Yvona TICHÝ Boris TOM Nikola PÁL Karol MAYER Jiří DOUBEK Michael POSPÍŠILOVÁ Šárka
Year of publication	2020
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Aims • To assess the risk of clonal expansion of minor-clone TP53 mutations • To evaluate the clinical impact of TP53 mutations with different variant allele frequencies (VAFs) ...in patients entering first-line treatment
Related projects:	Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit VI Alternative mechanisms of deregulation of the p53 pathway in chronic lymphocytic leukemia Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease progress The role of transposable element activity in hematological malignacies