Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

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Authors

SOJKA Martin FOJTŮ Michaela FIALOVÁ Jindřiška MASAŘÍK Michal NEČAS Marek MAREK Radek

Year of publication 2019
Type Article in Periodical
Magazine / Source Inorganic Chemistry
MU Faculty or unit

Central European Institute of Technology

Citation
Web DOI: 10.1021/acs.inorgchem.9b01203
Doi http://dx.doi.org/10.1021/acs.inorgchem.9b01203
Keywords metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic
Attached files
Description We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.
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