Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance

Investor logo

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

MOZGOVÁ Iva FAJKUS Jiří WILDHABER Thomas ROSZAK Pavel TREJO-ARELLANO Minerva S. FAJKUS Jiří ROSZAK Pawel KOEHLER Claudia HENNIG Lars

Year of publication 2018
Type Article in Periodical
Magazine / Source New Phytologist
MU Faculty or unit

Faculty of Science

Citation
Web http://www.newphytologist.com
Doi http://dx.doi.org/10.1111/nph.15082
Keywords Arabidopsis thaliana; CAF-1; Chromatin; Development; DNA methylation; epigenetics; histone
Description Shoot- and root-related growth phenotypes were progressively more affected in successive generations of CAF-1 mutants. Early and late generations of the fasciata (fas)2-4 CAF-1 mutant displayed only limited changes in gene expression, of which increasing upregulation of plant defense-related genes reflects the transgenerational phenotype aggravation. Likewise, global DNA methylation in the sequence context CHG but not CG or CHH (where H = A, T or C) changed over generations in fas2-4. Crossing early and late generation fas2-4 plants established that the maternal contribution to the phenotype severity exceeds the paternal contribution.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info