Capillary Electrophoretic Method with Fluorescence Detection as a Promising Tool for Screening of Beta-Secretase Inhibitors

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Authors	ŘEMÍNEK Roman SCHEJBAL Jan GLATZ Zdeněk
Year of publication	2018
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Alzheimer’s disease (AD) represents the most common cause of dementia. According to amyloid cascade hypothesis, pathogenesis of the disease could be slowed down or even stopped by inhibition of beta-secretase (BACE). Capillary electrophoretic (CE) methods are regarded as a promising tool for enzyme assays. A CE method with fluorescence detection for screening of potential BACE inhibitors was therefore introduced.
Related projects:	Vysoce efektivní systém založený na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako terapeutického cíle pro Alzheimerovu chorobu