Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene

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Authors

SEDLÁKOVÁ Veronika VORÁČ Zbyněk JAROŠ Josef KOPECKÁ Radka KLOUČKOVÁ Michaela SVOBODA Michal STREIT Libor DUMKOVÁ Jana VAŠÍČKOVÁ Kateřina ALBERTI Milan HAMPL Aleš

Year of publication 2018
Type Article in Periodical
Magazine / Source Materials Letters
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0167577X18309297?via%3Dihub
Doi http://dx.doi.org/10.1016/j.matlet.2018.06.023
Keywords Phosphazene; Amino; Electrospinning; Biomaterials; Biomimetic; Morphology
Description Here we report for the first time that blending hexaamino-cyclo-triphosphazene with either poly-epsilon-caprolactone or poly-L-lactic acid enables the generation of blended electrospun scaffolds with enhanced bioactivities. These hexaamino-cyclo-triphosphazene-modified fibers significantly promote cell adhesion, spreading, metabolism, and proliferation. In addition to that we also report more efficient hexaaminocyclo-triphosphazene synthesis with a higher yield and purity.
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