Cellular structural biology of nucleic acids

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This publication doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	DŽATKO Šimon KRAFČÍKOVÁ Michaela FIALA Radovan FESSL Tomáš LOJA Tomáš CARON C. GRANZHAN A. TEULADE FICHOU M.P. MERGNY J.L. TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš
Year of publication	2017
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	The nucleic acid structure, particularly that of DNA, is sensitively modulated by non-specific physical and chemical environmental factors such as nucleic acids concentration, water activity, molecular crowding, viscosity, temperature, pH and/or concentration and nature of counter ions. Existence of environmentally promoted conformational polymorphism thus indicates that characterization of DNA structure, dynamics, and DNA-ligand/protein interactions should be ideally performed under native conditions in complex environment of living cells.
Related projects:	Charakterizace struktury nukleových kyselin v komplexním prostředí živých buněk pomocí vysoce rozlišené NMR spektroskopie CEITEC 2020