Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients

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Authors

KANTOROVÁ Barbara MALČÍKOVÁ Jitka STRÁNSKÁ Kamila BORSKY Marek PLEVOVÁ Karla SMARDOVA Jana RADOVÁ Lenka TOM Nikola TRBUSEK Martin DIVISKOVA Eva FRANCOVA SKUHROVA Hana NAVRKALOVÁ Veronika DOUBEK Michael BRYCHTOVA Yvona MAYER Jiří POSPÍŠILOVÁ Šárka

Year of publication 2017
Type Article in Periodical
Magazine / Source British journal of haematology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03
Doi http://dx.doi.org/10.1111/bjh.14176
Field Oncology and hematology
Keywords EVOLUTION; HETEROGENEITY; CLL
Description The clinical course in chronic lymphocytic leukaemia (CLL) patients is diverse, reflecting the heterogeneous biological background of this disease (Guieze & Wu, 2015). Among reported defects, mutations in NOTCH1 and TP53 genes represent potent CLL progression drivers and contribute to disease chemo-refractoriness (Fabbri et al, 2011; Malcikova et al, 2015). Although parallel occurrence of NOTCH1 mutations and TP53 defects has been noted in CLL patients (Weissmann et al, 2013; Stilgenbauer et al, 2014), the clonal composition of these coexisting aberrations has not been yet studied. To clarify this phenomenon, we examined CLL patients with concurrently detected hotspot NOTCH1 and TP53 mutations using single cell analysis.
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