Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish

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Authors	MACÍKOVÁ Petra GROH Ksenia J. AMMANN Adrian A. SCHIRMER Kristin SUTER Marc J.-F.
Year of publication	2014
Type	Article in Periodical
Magazine / Source	ENVIRONMENTAL SCIENCE & TECHNOLOGY
MU Faculty or unit	Faculty of Science
Citation
web	http://pubs.acs.org/doi/abs/10.1021/es502711c
Doi	https://doi.org/10.1021/es502711c
Field	Water pollution and control
Keywords	ENVIRONMENTAL RISK-ASSESSMENT; TANDEM MASS-SPECTROMETRY; SEWAGE-TREATMENT PLANTS; ZEBRAFISH DANIO-RERIO; RAINBOW-TROUT; WASTE-WATER; GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; ONCORHYNCHUS-MYKISS; SURFACE WATERS
Description	This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from
Related projects:	Centrum pro výzkum toxických látek v prostředí Centrum pro výzkum toxických látek v prostředí