MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME

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Authors	ŠEBERA Jakub TRANTÍREK Lukáš FUKAL Jiří TANAKA Yoshiyuki SYCHROVSKÝ Vladimír
Year of publication	2014
Type	Article in Periodical
Magazine / Source	Chemické listy
MU Faculty or unit	Central European Institute of Technology
Citation
web	http://chemicke-listy.cz/docs/full/2014_04_364-367.pdf
Field	Biochemistry
Keywords	NUCLEIC-ACID BASES; GLYCOSIDIC BOND-CLEAVAGE; HUMAN 8-OXOGUANINE GLYCOSYLASE; AB-INITIO; TRANSITION-STATE; PROTEIN HOGG1; HARTREE-FOCK; OGG1 GENE; RECOGNITION; GUANINE
Description	This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.
Related projects:	CEITEC - Central European Institute of Technology