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Project information
Unraveling the potential of new generation polymethinium salts for migrastatic and photoactivated therapies

Information

This project doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.
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Project Identification
GA25-15918S
Project Period
1/2025 - 12/2027
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
Charles University

Improving patient clinical outcomes necessitates the exploration and implementation of innovative treatment modalities. Migrastatic-applied therapy (MAT) and photoactivated therapies (PAT) present a promising approach due to their minimal systemic toxicity and broad application spectrum. Designed as mitochondrial probes, polymethinium salts (PMS) exhibit excelent qualities as stable fluorescence, high mitochondria specifity, rapid cellular uptake and great photostability. Our previous work has established the efficacy of first-generation PMS (fgPMS) in targeting mitochondrial function to inhibit cell motility, highlighting the potential of mitochondrial targeting in MAT, however the specific molecular mechanism underlying this effect remains unknown. Furthermore, PMS's unique photochemical properties, including a broad absorption spectral range, position them as ideal candidates for dual therapeutic action, targeting systemic malignancies and chronic inflammations.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Publications

Total number of publications: 2

2026

2025

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