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Project information
Structural characterisation of the interplay between transcription and DNA repair

Information

This project doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official project website can be found on muni.cz.
Project Identification
GM21-10464M
Project Period
1/2021 - 12/2025
Investor / Pogramme / Project type
Czech Science Foundation
  • JUNIOR STAR
MU Faculty or unit
Central European Institute of Technology

The interplay between DNA repair and transcription is a complex and poorly understood. On one hand, transcription is one of the mayor sources of DNA damage. On the other hand, under particular circumstances, cells use transcription machinery to efficiently initiate DNA repair. As the in vivo methods are inherently unable to uncover the causal relationships between DNA repair and transcription, we decided to study the above-mentioned processes by a combination of biochemical and structural approaches. The aim of the project is to determine the 3D structures of RNAPII with key factors promoting the cross-talk between transcription and DNA repair (BRCA1, SENATAXIN), coupled with a thorough biochemical analysis of the complexes. The combination of these approaches will provide a complex and detailed characterisation of the interplay between DNA repair and transcription.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being

Publications

Total number of publications: 3

2024

2023

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