Project information
Vliv pneumologické medikace na funkce lidských kardiomyocytů
- Project Identification
- NU20-06-00156
- Project Period
- 5/2020 - 12/2023
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
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Faculty of Medicine
- MUDr. Martin Pešl, Ph.D.
- Mgr. Bc. Deborah Beckerová
- Debora Ledahudcová
- Mgr. Vladimír Rotrekl, Ph.D.
- Mgr. Šimon Vrana, Ph.D.
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Kristián Brat, Ph.D.
Projekt se bude zabývat mechanizmem vzniku kardiomyopatie působením kombinací bronchodilatačních léčiv, za použití kardiomyocytů odvozených z pluripotentních kmenových buněk, získaných reprogramací primárních kultur z biopsií pacienů.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 33
2026
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Generation of an arrhythmogenic right ventricular cardiomyopathy-patient-derived iPS cell line with PKP2 and AKAP9 mutation (MUNIi022-A)
Stem cell research, year: 2026, volume: 95, edition: 1, DOI
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Mechanobiological distinction of focal and conductive arrhythmias by atomic force microscopy
Year: 2026, type: Conference abstract
2025
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3D elektromechanické biosenzory buněk pro screenig léčiv a onemocnění
Year: 2025, type: Appeared in Conference without Proceedings
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Arrhythmogenic Potential of Aminophylline and Its Modulation by Salbutamol: Insights from Human Pluripotent Stem Cell-Derived Cardiomyocytes
Year: 2025, type: Conference abstract
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DETEKCE ARYTMOGENÍHO POTENCIÁLU LÉČIV U DVOJICE KLASTRŮ KARDIOMYOCYTŮ S POMOCÍ MIKROSKOPIE ATOMÁRNÍCH SIL (AFM)
Year: 2025, type: Conference abstract
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Protective role of salbutamol against aminophylline-induced arrhythmias in an hPSC-based cardiac model
EUROPEAN RESPIRATORY JOURNAL, year: 2025, DOI
2024
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A narrative review of theophylline: is there still a place for an old friend?
Journal of Thoracic Disease, year: 2024, volume: 16, edition: 5, DOI
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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner
Biomedicine & Pharmacotherapy, year: 2024, volume: 181, edition: December 2024, DOI
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Microphysiological Analysis of Cardiomyocyte Function in 3D Organoids
Year: 2024, type: Conference abstract
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Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model
Scientific Reports, year: 2024, volume: 14, edition: 1, DOI