Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids
| Autoři | |
|---|---|
| Rok publikování | 2026 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Diabetic cardiomyopathy is a disease characterized by structural alterations of the cardiac muscle, fibrosis, and reduced systolic function, which can ultimately lead to heart failure. Chronic hyperglycaemia is associated with elevated oxidative stress, and we hypothesize that it could induce DNA damage and/or changes in signalling pathways effecting metabolism and thus alter the fate of stem or progenitor cells. This could represent a potential mechanism contributing to the pathogenesis of diabetic cardiomyopathy. To investigate the molecular mechanisms underlying this disease, we employ a model based on human pluripotent stem cells and derived cardiac organoids exposed to aberrant glucose concentrations. Using this model, we analyse the impact of hyperglycaemic conditions on cardiac tissue development and the onset of pathological changes. For instance, aberrant glucose levels result into impaired progression through already early stages of organoid differentiation, particularly mesoderm specification and onset of maturation. These insights may contribute to a deeper understanding of the cellular and molecular mechanisms linking diabetes to cardiomyopathy and provide novel targets for prevention or therapy. Project was funded by project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) – Funded by the European Union – Next Generation EU. |
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