Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Inorganic Chemistry Communications |
| MU Faculty or unit | |
| Citation | |
| web | http://linkinghub.elsevier.com/retrieve/pii/S1387700310003084 |
| Field | Inorganic chemistry |
| Keywords | Decomposition of copper complexes; Kinetics; Electrolyte media; Copper-64 radiopharmaceuticals |
| Description | The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different chloride concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals. |
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